Chemical-genetic network

Fig. 6-16 A chemical-genetic network representing a graph C = (V, E) (data from [82]). Each node (V circles) represents a biologically active small molecule or a phenotypic assay and each edge (E line) represents an observed biological activity. Shown here is an undirected, unweighted, bipartite graph with a total of 426 nodes (V)...

John Ross, Igor Schreiber, Marcel O. Vlad, and Adam Arkin. Determination of Complex Reaction Mechanisms Analysis of Chemical, Biological, and Genetic Networks. Oxford University Press 2005... 

Collaborative research initiatives for the use of chemical genetics to facilitate discovery of potential cancer (or other) therapeutics by the initiative for Chemical Genetics at the National Cancer Institute (50) and to facilitate the discovery of netv targets and drug candidates by the Chemical Genomics Center at the National Institutes of Health (51) have been initiated. These initiatives will result in databases that contain information that most likely will be valuable to the study of cellular signaling networks. 

Carlson SM, White FM (2011) Using small molecules and chemical genetics to interrogate signaling networks. ACS Chem Biol 6(l) 75-85... 

Special consideration is given to the effects on the increasingly better understood biological, biochemical and genetic networks as well as the chemical and biotechnological systems of manufacture, lecoveiy and formulation. 

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