Chelation entropic nature

There are many factors to be considered in examining the enhanced stability provided by chelating ligands. These include both thermodynamic and kinetic effects. Thermodynamically, an early explanation was that the origin of the effect was entropic in nature. This can be seen by comparing reactions in (4 and 5). The number of species in solution remains the same before and after the reaction in (4), and the overall AG is favorable at —51.8kJmol In (5), however, the four reactant species are replaced by seven product... 

It is also well known that both the chelate and macrocycle effects are entropic in nature. As an indirect demonstration, the analysis of available literature formation... 

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