Chelate effect kinetic effects

Hydration enthalpy Stability or formation constant Overall and stepwise stability constants Chelate effect Macrocyclic effect Preorganization Equilibrium template effect Kinetic template effect Self-assembly... 

In the case of inert cobalt(m) complexes it is possible to isolate the chelated products of the reaction. Let us return to the hydrolysis of the complex cations [Co(en)2(H2NCH2C02R)Cl]2+ (3.1), which contain a monodentate iV-bonded amino acid ester, that we encountered in Fig. 3-8. The chelate effect would be expected to favour the conversion of this to the chelated didentate AO-bonded ligand. However, the cobalt(iu) centre is kinetically inert and the chloride ligand is non-labile. When silver(i)... 

D. G. Knorre and N. M. Emanuel. Voprosy Khim. Kinetikiy Kataliza i Reaktsionnoi Sposobnostiy Akad. Nauk S.S.S.R. 1955, 106-16. Reaction kinetics review, H bond, chelation, and solvent effects. 

Biologically active platinum complexes have now been under investigation for nearly two decades. The large data base on structure-activity relationships has revealed a number of principles as well as raised new questions. Mechanistically, the aquation of the compounds and their ability to cause intrastrand cross-links in defined regions of DNA appear to be the chemical events most closely associated with antitumour activity. The reaction kinetics of the compounds in aqueous systems which may be influenced by chelate effects, steric hindrance of bulky ligands or metal oxidation state have been studied for... 

Marks and co-workers provided a most valuable examination of absolute bond disruption enthalpies of various relevant metalorganic ligands X in Cp 2Sm-X. The data were obtained by anionic titration calorimetry in toluene (Fig. 4) [41 ]. Although the Ln-X bonds seem to be thermodynamically very stable, they usually display kinetic lability due to high ligand exchange ability, chelating and solubility effects. 

---