Chartelline skeleton

Further, in continuation to the synthesis of chartellines, an approach was developed by Baran et al. to construct macrocyclic skeleton and 5-lactam functionality required for chartellines, securamines and securines [73],... 

Compound 158 was transformed into aldehyde 159 by performing a sequence of reactions and then it was converted into compoimd 161. Compound 161 on bromination followed by key transformations gave core skeleton 163, which after TMSE deprotection and decarboxylation gave natural product chartelline C (145) (Scheme 13) [74], Synthetic studies as well as synthesis of precursors of chartellines have also been reported in literature [75-80],... 

Iwasaki, K, Kanno, R., Morimoto, T., Yamashita, T., Yokoshima, S., Fukuyama, T. Synthetic studies on chartelline C stereoselective construction of the core skeleton Angew. Chem. Int. Ed. 2012, 51, 9160-9163. 

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