Chaperones function, regulation

Ilb HDAC6 Cytoplasm Regulation of molecular chaperone function Regulation of aggre-some function Regulation of microtubule stability and function... 

Ballinger, C. A., P. Connell, Y. Wu, Z. Hu, L. J. Thompson, L. Y. Yin, and C. Patterson. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol. 19 4535-45.1999. 

C. Regulation of Expression by Copper and Copper Chaperone Function... 

Scroggins BT et al (2007) An acetylation site in the middle domain of Hsp90 regulates chaperone function. Mol Cell 25(1) 151-159... 

Kirschke, E., Goswami, D., Southworth, D., et al. (2014) Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles. Cell, 157 (7), 1685-1697. 

In addition to questions about transcriptional regulation of the HS response, many are directed at the function of HS proteins as chaperones. How they accomplish this function and how they guide intracellular proteins to their appropriate compartment are areas of active research and discussion. 

In contrast to inhibitor 1, DARPP-32 and NIPP1, which regulate signal transduction, the function of inhibitor 2 appears to be different. There is evidence that inhibitor 2 associates with PP1, as the phosphatase is newly synthesized and contributes to the proper folding of the enzyme [40]. Inhibitor 2 can thus be considered a chaperone protein. The inactive PP 1-inhibitor 2 complex can then be activated upon phosphorylation of inhibitor 2 by glycogen synthase kinase-3. Whether this process is regulated in neurons in association with synaptic activity remains unknown. 

Figure 1. Different histone chaperones in the key histone metabolic pathways Functions of histone chaperones range from the storage of newly synthesized histones in the cytoplasm, its transfer into the nucleus and in histone assembly into nucleosomes. Apart from diis die histone chaperones are also involved in histone exchange, maintenance of heterochromatin and in the regulation of chromatin structure during transcription. (See Colour Plate 10.)...

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