Chaperone-mediated folding

Langer, T., Lu., C, Echols, H., Flanagan, J, Hayer, M.K., Hartl, F.-U. (1992). Successive action of Dnak, DnaJ, GroEL along the pathway of chaperone mediated protein folding. Nature 356, 683-689. 

When applied to whole HeLa cells, 193 proteins were identified, with diverse biological functions including signal transduction, protein synthesis, and chaperone-mediated protein folding. Of the proteins identified in this study, 56% were not previously reported to possess redox-active cysteines, and 93% were not reported to undergo sulfenic acid modification [172]. 

Young JC, Agashe VR, Siegers K, Hartl PU. Pathways of chaperone-mediated protein folding in the cytosol. Nature Revs. Cell Biol. 2004 5 781-790. 

Noorwez SM, Kuksa V, Imanishi Y, Zhu L, FUipek S, Pal-czewski K, Kaushal S. Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mntant associated with autosomal dominant retinitis pigmentosa. J. Biol. Chem. 2003 278 14442-14450. 

Fink AL. (1999) Chaperone-mediated protein folding. Physiol Rev 79, 425-449. 

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