Channels orthogonal capacity

Fig. 9.3.15 Probability of false positives and ROC output vs. orthogonal channel capacity (OCC).

The extent to which the orthogonal channel capacity (OCC) is available for each analysis, as the full capacity cannot always be harnessed, e.g., with an array of polymer film sensors where some polymers may not have any interaction with an analyte, or with some mass values of an analyte mixture not being represented in a mass spectrum. Appropriate OCC discounts may need to be derived. 

Two-dimensional (2D) separation systems are of interest because of their increased peak capacity over one-dimensional separations. Microfabricated devices (microchips) are potentially useful for multidimensional separations because high-efficiency separations can be achieved and small sample volumes can be manipulated with minimal dead volumes between interconnecting channels. Various techniques may be adopted for the fabrication of chromatographic columns in microchips for p-CEC following integration with other orthogonal separation methods as well as sample pretreatment proaches for rapid, automated analysis of more complicated biosamples with possible coupling to mass spectrometric detection. 

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