Benzalacetophenone chalcone

Phenyl /rans-styryl ketone (Chalcone) Benzalacetophenon D11/7... 

Benzalacetophenone (Chalcone) [94-41 -7] M 208.3, m 56-58", b 208"/25mm, pK -5.73 (aq H2SO4). Crystd from EtOH wanned to 50° (about 5mL/g), iso-octane, or toluene/pet ether, or recrystd from MeOH, and then twice from hexane. SKIN IRRITANT. 

It is interesting to note that condensation of the N,N-bis(silylated) enamine 538 with a variety of chalcones such as benzalacetophenone 735 proceeds, via 539 and subsequent cyclization and oxidation, to pyridines such as 540 [106, 108] whereas persilylated co-amino ketones such as the 2-substituted pyridine 541 cyclize, via 542, in 29% yield, to the pyrrole 543 [109] (Scheme 5.36). 

Benzalacetophenone (Chalcone) [94-41-6] M 208.3, m 56-58 . Crystd from EtOH warmed to 50 ... 

The Aldol Condensation Reaction Preparation of Benzalacetophenones (Chalcones)... 

In this experiment, procedures are given for preparing benzalacetophenones (chalcones). You should choose one of the substituted benzaldehydes and react it with the ketone, acetophenone. All the products are solids that can be recrystallized easily. 

Benzalacetophenones (chalcones) are prepared by the reaction of a substituted benzaldehyde with acetophenone in aqueous base. Piperonaldehyde, p-anisaldehyde, and 3-nitrobenzaldehyde are used. 

In Experiment 37, you were introduced to the aldol condensation reaction, which you used to prepare a variety of benzalacetophenones or chalcones. In this experiment, you will again prepare chalcones, but you will do so in a guided-inquiry experiment that simulates some of the methodology that you are likely to use in research. 

You will select from a variety of substituted benzaldehydes (1) and substituted acetophenones (2) to prepare benzalacetophenones (chalcones) (3) that bear a combination of substituents in each of the aromatic rings (see figure). 

In Experiment 37 ("The Aldol Condensation Reaction Preparation of Benzalacetophenones"), substituted benzaldehydes are reacted with acetophenone in a crossed aldol condensation to prepare benzalacetophenones (chalcones). This is illustrated in the following reaction, where Ar and Ph are used as abbreviations for a substituted benzene ring and the phenyl group, respectively. ... 

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