Chain Elongation of Aldehydes through Nucleophilic Additions

Chain Elongation of Aldehydes through Nucleophilic Additions... [Pg.641]

The Nef reaction has been employed for over fifty years in carbohydrate synthesis. A two-step process referred to as the Snowden method has been widely used to effect the chain elongation of sugars via the nucleophilic addition of the nitromethane anion to an aldehyde group followed by Nef reaction to provide a new aldehyde.6 For example, in early studies Sowden and Fischer described the conversion of 35 to 36 through addition... [Pg.648]

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