Chain-bridged, synthesis salts

Pariser-Parr-Pople calculations, 72 calculations of thiazolocyanines, 73 of thiazolium salts, 31 Pentamethine thiazolocyanines, chain-bridged, synthesis of. 58 cleavage of, 63 nomenclature of. 26 synthesis of, 56... 

Ethyl-2-methyi-4-phenylthiazolium salts, on hydrobase of, 39 3-Ethyi-5-methyl-2-(p-dimethylamino-styiyl) thiazolium iodide, 29 Ethyl orthoformate, condensation with, thiazolium salts, 49 in synthesis of. chain-bridged thiazolocyanines, 58 thiazolocyanines. 58... 

Biogenic polyamines are long linear chains composed of 3 or more amino groups interconnected by methylene bridges (CH2)n where n typically is 3-5. Spermine is a quintessential example, isolated as its crystalline phosphate salt from human sperm by Anton van Leeuwenhoek in 1678. Spermine, and its bio-genetic precursor spermidine, occur in almost all tissues and they play a major role in the modulation of calcium-dependent immune processes and in cell differentiation and proliferation. The discovery that polyamines are structural components of potent spider neurotoxins has lent a certain frisson to their synthesis and it has elevated one of the dullest groups of natural compounds an aura of interest. 

The synthesis of the T1 salts of hydrotris(mercaptothiazolyl)borate (Tz) and hydrotris(mercaptobenzothiazolyl)borate (Tbz) has been reported by the Reglinski group. These species can be used as convenient ligand transfer reagents. [Tl(Tbz)]oo exhibits a bridging thione linking Tl(Tbz) units (Fig. 5.19) into zig-zag one-dimensional polymeric chains.84... 

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