CGI-PDE Regulatory Domain

1 Isolation and regulation of the cGMP-inhibited cyclic-AMP phosphodiesterase from human erythroleukemia frlEL) cells) 

2 Cloning of human cGI-PDEfrvm HEL cells and platelets, expression in yeast and localization of catalytic domain by deletion mutagenesis 

3 Structural characteristics ofcAMP and cGMP binding sites in proteins Sites for cAMP 

The cGMP sites in PDEs are less well understood. From homology consideratiorrs, the re 

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