CETP gene

The gene encoding CETP is located on the long arm of chromosome 16 (16ql2-21), spans approximately 25kbp and harbors 16 exons and 15 introns. The molecule mass of its mature protein product is 74 kDa. Major sites of CETP gene expression in humans are the... 

In 1998 the REGRESS group published data, which showed that the TaqlB polymorphism in intron 1 of the cholesterol-ester transfer protein (CETP) gene predicts whether men with coronary artery disease would benefit from treatment with pravastatin or not [60]. Pravastatin therapy slowed the progression of coronary athero-... 

Freeman DJ, Wilson V, McMahon AD, Packard CJ, Gaffney D. A polymorphism of the Cholesteryl Ester Transfer Protein (CETP) gene predicts cardiovascular events in the West of Scotland Coronary... 

Figure 13.2 Effect of inserting a human CETP gene on cholesterol lipoproteins in E3L mice fed a Western-type diet containing 0.25% cholesterol. The E3L.hCETP mouse has shown to respond to statins, fibrates, and the new CETP inhibitor torce-trapib in a similar way as humans do, as manifested by decreased apoB-containing lipoproteins and increased HDL levels.

Our data suggested that the expression of CETP in this strain of transgenic mice, in which the human CETP gene was... 

Corbex, M., Poirier, O., Fumeron, F., Betoulle, D., Evans, A., Ruidavets, J.B., Arveiler, D., Luc, G.,Tiret, L., and Cambien, F. (2000) Extensive Association Analysis Between the CETP Gene and Coronary Heart Disease Phenotypes Reveals Several Putative Functional Polymorphisms and Gene-Environment Interaction, Genet. Epidemiol. 19,64—80. 

Figure 5.16 Quantitation of gene expression by PCR/primer extension and MALDi-TOF-MS in a mixture model system. Depicted is a scatter plot of calculated allele ratios (based on mass signal peak area rations of primer extension products) for expression analysis of the CETP gene. Data points represent the average of triplicate reactions. Expected ratios are depicted as a solid line, and observed values as dots. In this model system two artificial templates (90bp) were designed based on the sequence of the CETP gene mRNA (Accession AC023825). One of the templates matched this region of the CETP gene exactly. The second had a 1 bp...

As mentioned earlier, decreased HDL-C levels constitute a major risk factor for CAD and LEAD. A novel therapeutic approach to raise HDL is inhibition of cholesteryl ester transfer protein (CETP) (123). Individuals with CETP deficiency as a result of molecular defects in the CETP gene, have markedly elevated plasma levels of HDL-C and apoli-poprotein A-I (124). 

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