Cerebellar nuclei primates

Only few observations in primates are available on the corticonuclear projection of the posterior lobe. Haines and Whitworth (1978) and Haines and Patrick (1981) studied the projection of the paramedian lobule and the paraflocculus in the tree shrew Tupaia glis). They concluded that , 3 and a D zone, with a similar topography and corticonuclear projection as in the cat, were present in the paramedian lobule of the tree shrew. The C2 and the D zone continued into the paraflocculus, where the D zone could be subdivided into D, and Dj zones on the basis of its differential projection to the lateral cerebellar nucleus. The organization of the posterior vermis in primates (Haines, 1975a,b) will be dealt with in the Sections on the vestibular cerebellum (6.1.5.) and the olivocerebellar projection (6.3.3.3.). 

In the 1950s Cooke [135] and Dow [136] described their work in rats and primates showing that stimulation of the cerebellum had effects on the electroencephalogram and the frequency of seizures. On this basis, in 1973 Cooper and colleagues reported the use of chronic cerebellar stimulation in patients with epilepsy. They also reported benehts for spasticity [119]. Unfortunately, several subsequent clinical series were unable to replicate Cooper s results with epilepsy [137]. Also in the 1970s, Chkhenkeli reported preliminary results of stimulating the caudate nucleus for epilepsy (followed in 1997 by a larger series) (Chkhenkeli and Chkhenkeli, 1997). 

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