Ceramides structural analogs

Other Structural Analogs of Ceramide with High Antiproliferative Activity... 

Other novel structural analogs of ceramide, such as Cig-serinol and (2S,3R)-(4E,6E)-2-octanoylamidooctadecadiene-l,3-diol (4,6-diene-ceramide) induced apoptosis in various human cancer cells (Bieberich et al., 2000 Struckhoff et al.,... 

Structural analogy with sphingosine prompts a predicted metabolic pathway for FB j. In Fig. 5 it is predicted that FB) may be (i) acylated by ceramide synthetase with or without removal of the side chains by carboxylesterase action and (ii) de-aminated by either monoamine oxidases or mixed function oxidases with or without esterase action to yield metabolites that would be expected to be inactive, since a free amino group appears to be required for activity. However, none of the metabolites predicted in Fig. 5 are likely to be highly active. 

Figure 13 Structures of a cationic ceramide analog and /S/-(N -phenethylthiocarbamoyl)-sphingosine.

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