Ceramide biosynthesis

Merrill, A.H.Jr., and Wang, E, 1992, Enzymes of ceramide biosynthesis. Methods Enzymol. 209 427-437. 

Involvement of de novo ceramide biosynthesis in lymphotoxin-induced oUgodendrocyte death. Neuroreport 10 2373-2376. 

Xu, J., Yeh, C.H., Chen, S.W., Turning He, Sensi, S.L., Canzoniero, L.M.T., Choi, D.W., and Hsu., C.Y., 1998, Involvement of de novo ceramide biosynthesis in tumor necrosis factor-a cycloheximide-induced cerebral endothelial cell death. J. Biol. Chem. 273 16521-16526. 

Ulrich S, Huwiler A, Loitsch S, Schmidt H, Stein JM. 2007. De novo ceramide biosynthesis is associated with resveratrol-induced inhibition of ornithine decarboxylase activity. Biochem Pharmacol 74 281-289. 

Figure 11 Structures of synthetic inhibitors of ceramide biosynthesis.

Plo, I., Ghandour, S., Feutz, A.C., Clanet, M., Laurent, G., and Bettaieb, A. Involvement of de novo ceramide biosynthesis in lymphotoxin-induced oligodendrocyte death. Neuroreport, 10, 1999, 2373-2376. 

Morell, P. Radin, N.S. (1970) Specificity in Ceramide Biosynthesis from Long Chain Basis and Various Fatty Acyl Coenzyme A s by Brain Microsomes , Journal of Biological Chemistry 245, 342-50... 

Figure 5. Ceramide biosynthesis (modified from Kolter and Sandhoff, 1999). PLP, pyridoxal phosphate. NADPH, nicotinamide adenine dinucleotide phosphate.

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