Cephamycin producing cultures

Of 27 cephamycin-producing cultures examined by Stapley et al. (1972), 26 were shown to be producers of cephamycins A and B, and only one culture produced cephamycin C. This is also true of the experiences at Squibb, where cephamycins A and B are frequently encountered but cephamycin C only rarely (J. S. Wells, E. Meyers, and R. B. Sykes, unpublished observations, 1979). The findings to date indicate that cephamycins A and B are almost invariably coproduced but not in the presence of cephamycin C. 

SF-1623, a cephamycin containing sulfothiomethyl at the 3-position (Table 1), is produced by certain cephamycin A- and B-producing cultures when grown in the presence of an alkali metal thiosulfate (Kojima et al., 1975 Inouye et al., 1975). 

Yegneswaran et al. (1991) used a Monte Carlo method and CTD similar to those of Namdev et al. (1991) to investigate the effects of dissolved oxygen on a culture of antibiotic producing Streptomyces clavuligerus. They found that the yield of cephamycin C was suppressed by almost 44% due to the Monte Carlo simulation as compared to constant period cycling. One limitation in the... 

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