Centrolobium robustum

Among leguminous Centrolobium species diarylheptanoids were first isolated from C. robustum in 1964 (5). It contains (-)-(R)-centrolobol (2), found later in several other plants too (Acer nicoense (Aceraceae) (6), Be tula pendula (Betulaceae) (24)) as well as two cyclic components, (3/ ,75)-centrolobin (67) and (3/ ,75)-de-0-methylcentrolobin (68) (47). First... 

The occurrence of opposite enantiomers of diarylheptanoids in closely related Centrolobium spp. and possibly even in variants of the same species (C. robustum var. macrochaete Mart, and C. robustum van microchaete Mart.) (1) is most interesting from biogenetic and phytochemical points of view. Diarylhej tanoids of the same chiral relationships - e.g. (+)centrolobin (32a), (+)-de-0-methyl cen-trolobin (32 b), and (H-)-centrolobol (31a) - co-occur and should therefore be biogenetically related (1). 

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