Central Nervous System chemokines developing

Alzheimer s disease in which the pathogenicity of amyloid peptides depends on proteases, namely secretases, involved in amyloid precursor protein (APP) maturation. This chapter will describe how the proteolysis of chemokines might participate in the neuropathogenesis of HIV infection, thus contributing to the development of the central nervous system disorder termed HIV-associated dementia (HAD). 

Besides the well-established role of cytokines in the immune system, several recent reports demonstrated that chemokines also play a role in the central nervous system (CNS) (B2, Ml3). In the CNS, chemokines are constitutively expressed by microglial cells, astrocytes, and neurons, and their expression can be increased after induction with inflammatory mediators (M13). Chemokines are involved in brain development and in the maintenance of normal brain homeostasis, and play a role in the migration, differentiation, and proliferation of glial and neuronal... 

Karman J, Chu HH, Co DO, Seroogy CM, Sandor M, Fabry Z (2(X)6) Dendritic cells eunplify T cell-mediated immune responses in the central nervous system. J Immunol 177 7750-7760 Kielian T, Hickey WF (2000) Proinflammatory cytokine, chemokine, and cellular adhesion molecule expression during the acute phase of experimental brain abscess development. Am... 

Until recently, chemokines and their receptors were believed to have evolved solely for the purpose of recruiting and activating immune cells during inflammation. As the known roles for chemokines increased through studies of their eflfects on hematopoiesis and lymphopoiesis, it became clear that they are important in the development and homeostasis of almost all tissues. In the central nervous system (CNS), investigations of the chemokines responsible for leukocyte recruitment into the CNS during various neuroinflammatory diseases lead to additional discoveries regarding their... 

---