Primitive neuroectodermal tumor central nervous

The features and differential diagnosis of central nervous primitive neuroectodermal tumor (cPNET) can be found in the Medulloblastoma section earlier in this chapter. Although cerebral PNET, cerebellar medulloblastoma, and pineoblastoma are all primitive neuroectodermal tumors by histology alone, the recent tendency has been to recognize the cerebral tumor as a PNET, the posterior fossa tumor as a medulloblastoma, and the pineal tumor as a pineoblastoma (see Box 20.3). It is this author s opinion that these tumors are all different and that their differences will eventually be revealed with better markers. The cerebral ganglioneuroblastoma and neuroblastoma are called PNET with advanced neuronal differentiation. ... 

Brustle O, Ohgaki H, Schmitt HP, Walter GF, Ostertag H, Kleihues P (1992) Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene. Cancer, 69 2385-2392. 

The polyphenotypic immunohistochemical prohle of MRT presents challenges in the differential diagnosis, particularly with DSRCT, RMS, choroid plexus carcinoma, and epithelioid sarcoma. In particular, the absence of INIl protein in proximal-type epithelioid sarcoma, in a subset of central nervous system primitive neuroectodermal tumors without a rhabdoid phenotype and in renal medullary carcinoma, suggests the existence of a wider family of hSNP5/INIl-deficient The lack of expression of INIl protein... 

CMV, cytomegalovirus CNS, central nervous system EMA, epithelial membrane antigen GFAP, glial fibrillary acidic protein HV, herpesvirus NF, neurofilament PML, progressive multifocal leukoencephalopathy PNET, primitive neuroectodermal tumor PNS, peripheral nervous system Mw, microwave starting in cold buffer for time noted. 

Burnett ME, White EC, Sih S. Chromosome arm 17p deletion analysis reveals molecular genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumors of the central nervous system. Cancer Genet Cytogenet. 1997 97 25-... 

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