Central composite design circumscribed

FIGURE 2.5. Circumscribed central composite design for three factors (at least 15 experiments). 

TABLE 2.18. Responses studied in the circumscribed central composite design (Table 2.14 with lal = 1.68, five center point replicates (exp 15-19)) applied during the optimization phase of the development of a chiral enantioseparation method in Reference 28 migration time of the first and the second enantiomer (t i and t j), and resolution between the two enantiomers Rs... 

Plackett-Burman design, full factorial design, circumscribed central composite design... 

Three types of central composite design can be constructed, namely the usual one with a > 1, called the central composite circumscribed (CCC) (Table 5), the central composite inscribed (CCI) when lal < 1, and the central composite face-centered (CCF), for which a = 1. The last results in a face-centered cube. 

In the Circumscribed Central Composite Design the length of the arms of the star is the square root of the number of variables. In that case, each variable has five levels (vs. the three levels of the Face-Centred Design), all the points are equidistant from the centre and the design spans a spherical domain... 

FIGURE 7 A graphical representation of a Circumscribed Central Composite Design with three variables. 

The levels are equally spaced, which is not the case in a circumscribed central composite design (except with four variables). This is very convenient from a practical point of view, because some variables can only be varied with discrete steps. 

In 2005, Rantanen et al. used on-line NIRS to monitor a laboratory-scale high shear wet granulation process. The study was a central-composite circumscribed design consisting of 17 runs and 3 variables ... 

ED (BGE optimization). Box-Behnken design, central composite face-centered design, central composite circumscribed design. Eactors CD concentration, voltage, temperature. Response resolution, migration time. 

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