Cellular signaling events

At least five distinct muscarinic receptor genes have been cloned and sequenced. The genes are called Wj to m5. They correlate with the M to M5 receptors identified pharmacologically. The subtypes differ in their ability to couple to different G proteins and, hence, to elicit cellular signaling events. 

This chapter discusses the anticarcinogenic effects of green tea catechins, especially EGCG in different organ sites and effects on cellular signaling events. 

Both PA and LPA nu also affect Ca homeostasis in stimulated platelets and US, maiqr Ca - mediated cellular signalling events. 

Dengiel, j. Akimov, V Olsen, J. V. Bunkenborg, J. Mann, M. Blagoev, B. Andersen, J. S. Quantitative proteomic assessment of very early cellular signaling events. Nature Biotechnol. 2007, 25, 566-568. 

Effective treatments for lipid A induced shock are not available, in part because the cellular signaling events induced by lipid A/LPS in mammalian cells are not fully understood. However, recent work has revealed some of the important signaling events that occur upon LPS activation. 

MAP kinase signaling promotes differentiation ofPC12 cells. Adaptor proteins are able to regulate the time course of signaling events, and therefore the cellular outcome. 

Despite the fundamental importance of receptor-catalyzed G protein activation in cellular signaling, relatively little is known about this process as compared to the other regulatory events in the G protein cycle. Crystal structures of inactive rhodopsin and G protein heterotrimers provide the structural context for the meaningful interpretation of the results of the numerous biochemical and biophysical studies described in the preceding sections. Enough data has been accumulated to begin to develop rudimentary models of the receptor-G protein complex that meet some of... 

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