Cellular retinol binding protein type

Retinol (vitamin A) is found in foods of mammalian origin in the form of retinyl ester, or in fruits and vegetables as carotenoids with provitamin A activity, especially P-carotene (provitamin A). In enterocytes, retinol binds to cellular retinol-binding protein type II (CRBPII), which directs the esterification by the enzyme lecithin retinol acyltransferase (LRAT). 

BASF AG CRBPII dba DBN DBU DIBAL-H DMAP DMF DMF-DMA DMPU HMDS HMPA HMPT H-LR LDA LDE LRAT MCPBA MOM NMO NMP PCC PhH = Badische Anilin- Soda Fabrik AG = cellular retinol-binding protein type II r dibenzylideneacetone = 1,5-diazabicyclo[4.3.0]non-5-ene = l,8-diazabicyclo[5.4.0]undec-7-ene = diisobutylaluminium hydride = 4-dimethylaminopyridine = A V-dimethylformamide = A,V-dimethylformamide, dimethylacetal = 1,3 -dimethyl-3,4,5,6-tetrahydro-2( 1H)-pyrimidone = hexamethyldisilazane = hexamethylphosphoramide = hexamethylphosphorous triamide = Hoffmann-La Roche = lithium diisopropylamide = lithium diethylamide = lecithin retinol acyltransferase = m-chloroperbenzoic acid = methoxymethyl = iV-methylmorpholine oxide = l-methyl-2-pyrrolidinone = pyridinium chlorochromate = benzene... 

Matt, N., C. K. Schmidt, V. Dup, et al. 2005. Contribution of Cellular Retinol-Binding Protein Type 1 to Retinol Metabolism During Mouse Development. Dev Dynam 233, no 1 167-76. 

Suruga, K., T. Goda, M. Igarashi, et al. 1997. Cloning of Chick Cellular Retinol-Binding Protein, Type II and Comparison to That of Some Mammals Expression of the Gene at Different Developmental Stages, and Possible Involvement of Rxrs and Ppar. Comp Biochem Physiol A Physiol 118, no 3 859-69. 

Posch, K. C, Burns, R B, and Napoli, J L. (1992) Biosynthesis of d -trans-retinoic acid from retinal recognition of retinal bound to cellular retinol binding protein (type I) as substrate by a purified cytosolic dehydrogenase J Biol Chem. 267, 19,676-19,682... 

Schaefer, W. H, Kakkad, B., Crow, J. A, Blair, I A, and Ong, D E. (1989) Purification, primary structure characterization, and cellular-distribution of 2 forms of cellular retinol-binding protein, type-II from adult-rat small-intestme. J Biol. Chem. 264,4212-4221... 

Inagami, S and Ong, D. E. (1992) Purification and partial characterization of cellular retinol-binding protein, type-2, from human small-mtestine. J Nutr 122, 450-456... 

Figure L Effects of dietary fats on the levels of -carotene dioxygenase activity and cellular retinol binding protein type II in rat intestinal mucosa. (Adapted with permission from reference 22. Copyright 1998 The American Society for...

Figure 4 Model of atRA biogeneration in mammals. REH, retinyl ester hydrolase (e.g., ES4 and ES10) TTR, transthyretin RAR-RXR, the heterodimer of retinoic acid receptors with retinoid X receptors atRCHO, all-frans-relinal atROH, all-frans-retinol CRBP(I), cellular retinol binding protein, type I LRAT, lecithin retinol acyltransferase SRBP, semm retinol binding protein. CRBP(I), CRABP(I), and CRABP(II) have been placed in the same cell for simplicity. This does not necessarily occur in vivo.

MacDonald, P N and Ong, D. E. (1987) Binding specificities of cellular retinol-bmding protein and cellular retinol-bmding protein, type II. J. Biol Chem 262, 10,550-10,556. 

---