Cellular retinaldehyde-binding protein

After the light-catalyzed reaction, all-mins-rctinal is released, which in turn is reduced to all-/ntm-retinol. To be used again by opsin, the all-/nins-retinol must be converted to I l-eis-rclinol. Isomerization occurs in the pigment epithelium of the retina. Oxidation of I l-cis-relinol to I -cis-relrnaldchyde occurs while retinol is bound to the protein cellular retinaldehyde-binding protein (CRALBP) by a microsomal enzyme in the pigment epithelium. ... 

K. 1993. Primary structure of alpha-tocopherol transfer protein from rat liver. Homology with cellular retinaldehyde-binding protein. J Biol Chem, 268, 17705-10. 

Saari, J. C. and Bredburg, D. L. (1987) Photochemistry and stereoselectivity of cellular retinaldehyde-binding protein from bovine retina. J. Biol. Chem. 262, 7618-7622. 

Martin-Alonso, J. M, Ghosh, S, Hernando, N., Crabb, J. W., and Coca-Prados, M (1993) Differential expression of the cellular retinaldehyde-binding protein in bovine ciliary epithelium. Exp. Eye Res. 56,659-669... 

Crabb, J. W., Goldflam, S., Hams, S. E., and Saan, J. C. (1988) Cloning of the cDNAs encoding the cellular retinaldehyde-binding protein from bovine and human retina and comparison of the protein structures J. Biol Chem. 263,18,688-18,692. 

Intres, R., Goldflam, S., Cook, J. R, and Crabb, J. W. (1994) Molecular cloning and structural analysis of tbe human gene encoding cellular retinaldehyde-binding protein. J. Biol. Chem. 269,25,411-25,418. 

Mutational mapping of the retinoid binding pocket in the cellular retinaldehyde-binding protein (CRALBP). Protein Sci. 6 (suppl. 2), 67, 76-M... 

Carlson, A., Bok, D, Crabb, J W., and Horwitz, J. (1993) Circular Dichroism Spectral Analysis of Native and Recombinant Cellular Retinaldehyde-Binding Protein. Invest Opthal Vis. Sci. 34, 831... 

Saan, J C. and Bredberg, L D. (1988) Purification of cellular retinaldehyde-binding protein from bovine retina and retinal pigment epithelium. Exp Eye Res 46,569-578... 

Sato, Y, Aral, H, Miyata, A, Tokita, S, Y amamoto, K, Tanabe, T and Inoue, K (1993) Primary structure of alpha-tocopherol transfer protein from rat liver. Homology with cellular retinaldehyde-binding protein. J. Biol. Chem., 268, 17705-17710. 

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