Cellular redox state oxidizing shift

A shift in the cellular reduction/oxidation (redox) state has been found to be involved in the process of apoptosis. Generally, the cellular redox state is a balance between the relative quantities of the intracellular oxidative substances (reactive oxygen species, ROS) and reductive substances (reduced glutathione, GSH). A microfluidic device method with laser-induced fluorescence (LIF) detection for simultaneous, rapid determination of intracellular ROS and GSH in apoptotic leukemia cells has been described. [Pg.2064]

Oxidation is favored over reduction during hypoglycemia, and all cellular redox pairs tilt their reactions toward oxidation in hypoglycemia. Thus, lactate/pyruvate, NAD/NADH, GSG/GSSG and NADP/NADPH all shift their equilibria toward the oxidized compound of the pair (Agardh et al., 1978). Whether the oxidized cellular state of hypoglycemia leads to oxidative damage to DNA or proteins is still unknown. [Pg.37]

A shift in the cellular reduction/oxidation (redox) state has been found to be involved in the process of apoptosis. [Pg.1213]

Big Chemical Encyclopedia