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Cell Therapies signaling proteins

In 2000, French researchers announced the first gene therapy cure in nine children with X-linked severe combined immune deficiency (X-SCID). This rare condition is caused by the inherited loss of a protein that is part of the docking site for critical immune system signal proteins. Because of this defect, children with X-SCID have no mature, working lymphocytes—critical immune system cells. [Pg.91]

Inhibition of the lipid modification cascade provides an alternative way to block aberrant signaling pathways and that opportunity can be exploited in anticancer therapy. As part of the growth factor, signaling of the false activation is transmitted by the mutated ras gene encoded proteins (Ras) and ultimately leads to uncontrolled cell growth. These typical GTP binding proteins are also subject to membrane anchoring and the biosynthesis of those Ras proteins can be blocked at the posttranslational prenylation step. [Pg.208]


See other pages where Cell Therapies signaling proteins is mentioned: [Pg.340]    [Pg.187]    [Pg.80]    [Pg.98]    [Pg.336]    [Pg.29]    [Pg.434]    [Pg.161]    [Pg.29]    [Pg.2218]    [Pg.2015]    [Pg.517]    [Pg.1971]    [Pg.336]    [Pg.240]    [Pg.113]    [Pg.127]    [Pg.168]    [Pg.626]    [Pg.247]    [Pg.250]    [Pg.152]    [Pg.562]    [Pg.626]    [Pg.209]    [Pg.281]    [Pg.87]    [Pg.318]    [Pg.669]    [Pg.953]    [Pg.1011]    [Pg.1106]    [Pg.1192]    [Pg.16]    [Pg.169]    [Pg.1314]    [Pg.472]    [Pg.497]    [Pg.533]    [Pg.105]    [Pg.275]    [Pg.286]    [Pg.2]    [Pg.12]    [Pg.117]    [Pg.58]    [Pg.152]    [Pg.491]   
See also in sourсe #XX -- [ Pg.240 ]




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Cell signal

Cell signalling

Cell therapy

Protein signals

Protein therapy

Signaling protein

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