Cell penetrating peptide Antennapedia

Cl. Astriab-Fisher A, Sergueev D, Fisher M, et al. (2002). Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides Effects on cellular uptake, binding to target sequences, and biologic actions. Pharmaceut. Res. 19 744-754. 

Identifying a cell-specific peptide with cell-penetrating characteristics is not always an easy task. The major drawback of conventional CPPs, such as TAT from HTV-TAT (Vives et al., 1997) and penetratin from the Antennapedia homeodomain (Derossi et al., 1994) are their lack of cell specificity, hampering their clinical development (Vives et al., 2008). 

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