Cell-membrane contact inhibition, role

Pediocin PA-1 was shown to dissipate the proton motive force and inhibit the amino acid transport in sensitive cells [75]. lipoteichoic acid is essential for non-specific pediocin AcH binding, and sensitive cells present a specific receptor that potentiates contact with the membrane [17,66]. Pediocin PA-1 displays an important M-terminal -Y-G-N-G-V-X-C- consensus common with other anti-Listeria bacteriocins such as sakacin A (= curvacin A) and P, and leucocin A. This finding suggests an important role of the N-terminus in either the recognition and/or activity of the pediocin-like bacteriocins. 

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