Cell-ECM interactions

Other cellular components that mediate cell-cell or cell-ECM interactions have also been shown to have bacterial specificity, including integrins (Cobum et ah, 1998 Leong et ah, 1990 Rezcallah et ah, 2005 Wang et ah, 2006 Watarai et ah, 1996), cadherins (Mengaud et ah, 1996), and selectins... 

Martins-Green, M. Dynamics of cell-ECM interactions. In Principles of Tissue Engineering, 2nd Ed. Lanza, R.P., Langer, R., Vacanti, J., Eds. Academic Press New York, 2000 33-55. 

A very interesting new class of proteins, the disintegrins, have been isolated as short ligands for the integrins (Weskamp and Blobel, 1994). The transmembrane forms of the family are characterised by metalloproteinase, disintegrin, cysteine-rich and EGF domains. These molecules are able to couple and thus inactivate normal integrins. Current ideas posit that these molecules are able to modulate cell-cell and cell-ECM interactions, both at the cell membrane and into the BL. Their ex-... 

Chitosan is a natural biopolymer that has many desirable characteristics as a scaffold or encapsulation material. It is a biodegradable, semicrystalline polysaccharide obtained by A-deacetylation of chitin, which is harvested from the exoskeleton of marine crustaceans. Chitosan is composed of glucosamine and A-acetyl glucosamine which are linked by glycosidic bonds. Being structurally similar to ECM components, chitosan provides cell-ECM interactions which guide cell behavior. 

Fig. 6 Scaffold Architecture Versus Cell Binding The inherent benefit of utihzing a nano-fibrous scaffold architecture (C) is increased surface area for protein absorption as well as enhanced cell-ECM interactions via cell-membrane receptors. Microscale architecture (A,B) is not as effective in this sense. From Exploring and Engineering the CeU Surface Interface by M.M. Stevens and J.H. George, 2005. Science, 310, p. 1135. Copyright 2005 byAAAS.

Rosso, E, Giordano, A., Barbarisi, M., Barbarisi, A., 2004. Erom cell-ECM interactions to tissue engineering. J. CeU. Physiol. 199,174-180. 

Lo, H.M. et al. (2007) Tea polyphenols inhibit rat vascular smooth muscle cell adhesion and migration on collagen and laminin via interference with cell-ECM interaction. / Biomed Sci 14 (5), 637-645... 

Figure 13.1 Schematic representation of cell-cell and cell—ECM interactions...

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