Cell division protein kinases CDKs

Figure 21.14 A summary diagram of how damaged DNA leads to arrest of the cell cycle. Damaged DNA activates a protein kinase which phosphorylates and hence stabilises p53, which stimulates transcription of the p21 gene which expresses a protein that arrests the cycle. CDK, cell cycle division kinase.

CAT-REL, vesicular catecholamine release CB-R, cannabinoid receptor CB1-R, CB2-R, cannabinoid receptors CBD, chitin-binding domain CBG, cortisol-binding globulin CBZ-R, central benzodiazepine receptor CCK-R, cholecystokinin receptor CDC, chrysanthemum dicarboxylic acid CDK, cell division kinase, cyclin-dependent protein kinase... 

Finally, dietary antioxidants may affect cell growth and possible tumorigenesis. When considering the treatment of endothelial cell neoplasms, limiting cell proliferation is one key aspect of an antiangiogenic strategy. Cyclins are molecules that directly stimulate cell division, and cyclin-dependent kinases (CDK) are needed to activate cyclin molecules. Thus the cyclin pathways represent an important target for tumor suppressors to inhibit. Two known tumor suppressor proteins that act in this maimer are... 

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