Fluconazole Celecoxib

Acenocoumarol, amiodarone, celecoxib, coumadin, dexamethasone, diclofenac, etoposide, fluconazole, fluoxetine, fluvas-tatin, fluvoxamine, ghmepiride, ghpizide, glyburide, ibuprofen, irbesartan, isoniazid, losartan, midazolam, phenylbutazone, phenytoin, rifampin, teniposide, tenoxicam, thiotepa, tolbutamide, torsemide, vitamin D, warfarin... 

NS AIDs ANTIFUNGALS -FLUCONAZOLE Fluconazole T celecoxib and possibly parecoxib levels Fluconazole inhibits CYP2C9-mediated metabolism of celecoxib and parecoxib Halve the dose of celecoxib and start parecoxib at the lowest dose... 

Antifungal fluconazole raises the plasma concentration of, and thus risk of toxicity from, celecoxib. 

Drug interactions May decrease antihypertensive effects of ACE inhibitors and angiotensin II antagonists decrease of antihypertensive and diuretic effects of thiazides and loop diuretics Agents are CYP2C9 substrates may decease effects of ACE inhibitors, thiazides, and loop diuretics fluconazole Increases levels of celecoxib may increase INR when added to warfarin... 

CYP2C9 20 10 Celecoxib Diclofenac Fluoxetine Fluvastatin Ibuprofen Irbesarten Naproxen Amitriptyline Phenytoin Tolbutamide Torsemide S-warfarin Rosiglitazone Amiodarone Fluconazole Fluvoxamine Fluvastatin Isoniazid Sertraline Sulfaphenazole Trimethoprin Zafirlukast Rifampin Clotrimazole Carbamazepine Hyperforin Phenobarbital Ritonavir... 

Fluconazole markedly raises celecoxib levels, whereas ketocona-zole has no effect on celecoxib levels. Fluconazole and ketocona-zole moderately increase the levels of valdecoxib (the main metabolite of parecoxib). Ketoconazole moderately raises etoricoxib plasma levels, but this is unlikely to be of clinical relevance. Fluconazole has no clinically relevant effect on lumiracoxib pharmacokinetics. 

The manufacturer notes that fluconazole 200 mg daily increased the AUC of a single 200-mg dose of celecoxib by 130% and increased the maximum level by 60%. Conversely, ketoconazole had no effect on the pharmacokinetics of celecoxib. ... 

For example, fluconazole, itraconazole, voriconazole, and posaconazole are commercially available antifungal agents that contain a triazole nnclens. Celecoxib is a nonsteroidal anti-inflammatory and analgesic agent of the pyrazole class. Isoxazole compounds such as Valdecoxib are selective COX-2 inhibitors used in the treatment of pain. 

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