Celecoxib anaphylaxis

Among the anaphylactic reactions to NSAIDs that result in different types of reaction (urticaria, angioedema, asthma, or hypotension), there have been very few reports of anaphylactic shock. However, anaphylaxis has been described in patients taking celecoxib (135,136) or rofecoxib (137). Rofecoxib caused anaphylaxis in a patient who had had a similar reaction to diclofenac, suggesting that COX-2 inhibitors may be not safe in all individuals who have adverse reactions to non-selective COX inhibitors. It also suggests that different mechanisms may be involved in patients with asthma and in those with anaphylactoid reactions to NSAIDs. 

Anaphylaxis due to celecoxib has been described (SEDA 26, 121). Life-threatening anaphylaxis, with urticaria, angioedema, and bronchospasm, has also been described 30 minutes after a dose of celecoxib for arthritis of the hip (128). 

Levy MB, Fink JN. Anaphylaxis to celecoxib. Ann Allergy Asthma Immunol 2001 87(l) 72-3. 

Immunologic Celecoxib-associated anaphylaxis has been described in a patient who had previously tolerated it [48" ]. 

Chamberlin KW, Silverman AR. Celecoxib-associated anaphylaxis. Aim Pharmacother 2009 43(4) 777-81. 

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