Celastrus paniculatus

Celastrus paniculatus Celastraceae Seed oil, bark, root, fruit Sharma and Dwivedi (1997)... 

Crude extracts of the root bark from Celastrus paniculatus Willd. (Celastraceae) demonstrated significant activity against cultured P. falciparum (93), and the active principle was shown to be pristimerin, a quinonoid triterpene. The family Simaroubaceae has also yielded a number of compounds with in vivo and in vitro antimalarial activity (94-96) including quassinoids. Bruceantin has been most extensively studied, but is very cytotoxic however, other quassinoids are relatively less toxic to cultured KB cells while retaining potent antimalarial activity (88). Plants from the Meliaceae are commonly used as febrifuges in Africa, and several limonoids from this family, such as nimbolide and gedunin, have also been found to produce moderate inhibition of cultured P. falciparum (97,98). 

Celastrus and Euonymus Alkaloids.— Two alkaloids bearing close structural similarity to the Maytenus bases (see Vol. 3 of these Reports) have been isolated from Celastrus paniculatus. The part structures (47a) and (47b) have been advanced for celapanine and celapanigme, respectively, on the basis of comparison of n.m.r. spectra with those of the Maytenus alkaloids whose structures have been determined by X-ray crystallographic analysis. The corresponding ses-quiterpenoid of (47) has also been isolated from C. paniculatus. 

Celastrus paniculatus Wind. Jotismati = Malkangni = Lakhan leaves hot water/oral made into a paste and applied emmenagogue for cuts and wounds 22, 23... 

Jain, M. K. Chemical examination of Celastrus paniculatus. Indian J. Chem. 1, 500 (1963). 

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