Cefuroxime antibacterial spectrum

SAR of Cefuroxime. The presenee of a 5y -alkoxiamino substituent in the drug molecule is closely associated with the prevalent P-lactamase activity in these eephalosporins. Perhaps its inclusion into the second generation cephalosporins is duly justified due to the faetthat its antibacterial spectrum bears a close similarity to that of cefamandole (see Seetion 3.2.1.2.1). 

New cephalosporins that are (or probably soon will become) available for parenteral use are cefamandole, cefuroxime and cefoxitin. These antibiotics seem to possess a broader spectrum of antibacterial activity, partly because of their greater resistance to various lactamases. Reports on the adverse reactions to these new drugs are still awaited. 

---