Cefur oxime

Cronberg S, Banke S, Bergman B, Boman H, Eilard T, Elbel E, Hugo-Persson M, Johansson E, Kuylenstierna N, Lanbeck P, Lindblom A, Paulsen O, Schonbeck C, Walder M, Wieslander P. Fewer bacterial relapses after oral treatment with norfloxacin than with ceftibuten in acute pyelonephritis initially treated with intravenous cefur-oxime. Scand J Infect Dis 2001 33(5) 339-43. 

Various antibiotics, including azlocillin, aztreonam, cefur-oxime, ceftazidime, chloramphenicol, colistin, flucloxacil-lin, gentamicin, imipenem, meropenem, piperacillin, tazobactam, temocillin, and ticarcillin, were incubated with this patient s serum. Only piperacillin and piperacillin -I- tazobactam caused agglutination in an indirect agglutination test. The authors concluded that the hemolytic anemia had been caused by piperacillin. 

The addition of tobramycin reduced the amount of cefur-oxime-induced endotoxin released per killed Escherichia coli to a level that was even lower than that of tobramycin alone, despite an increased killing rate (45). Increasing concentrations of tobramycin led to a rednction in endotoxin release, pointing to a possible benefit of once-daily dosing regimens. 

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