Cefoperazone indications

One of the prindpal deficiencies of the older cephalosponns was the lack of resistance to -lactamases. Compounds with improved jS-lactamase resistance have one or more of tire following characteristics a second, monovalent substiluenl on the a-carbon of the C-7 acyl group such as is found in cefamandole and cefoperazone a jy -oxime substiluenl, e.g., cefuroxime and ceftriaxone a methoxy, or formamido, substituent on the fl-laclam ring at tire 7 a-position such as in cefoxitin. However, these various substituents have different effects, and increased resistance to one enzyme does not indicate resistance to all (3-lactamases. 

Cefoperazone, a third-generation cephalosporin antibiotic (1 to 2 g q. 12 hours IM or IV), is indicated in the treatment of serious respiratory tract, intra-abdominal, gynecologic, and skin infections in bacteremia and in septicemia caused by susceptible organisms. 

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