Cefixime dosing

Other FDA-approved antibiotics for ABRS not included in the Sinus and Allergy Health Partnership or AAP guidelines cefaclor, cefprozil, cefixime, ciprofloxacin, erythromycin, loracarbef. cMaximum dose not to exceed adult dose. 

The treatment of choice is ceftriaxone, 125 mg intramuscularly (IM) as a single dose or cefixime, 400 mg orally in a single dose. Spectinomycin 2 g IM as a single dose is appropriate as a second choice. 

Cefixime 200-400 mg twice daily 8 mg/kg/day in one dose or divided in two doses... 

Adults-Once cefixime oral suspension is reconstituted, the recommended dose of the suspension is 400 mg daily. For the treatment of uncomplicated cervical/urethral gonococcal infections, a single oral dose of 400 mg is recommended. 

Includes ceftriaxone (IM) and cefixime (PO) used in single dose for gonorrhea, cefotaxime (active versus most bacteria causing meningitis), and ceftizoxime (B. fragilis). 

B) Treat her with a single oral dose of cefixime... 

Your 23-year-old female patient is pregnant and has gonorrhea. The past medical history includes anaphylaxis following exposure to amoxicillin. Worried about compliance, you would like to treat this patient with a single dose, so you choose (A) Cefixime Ceftriaxone Ciprofloxacin Spectinomycin Tetracycline... 

In 8 healthy subjects the AUC and peak serum levels of a single 200-mg dose of cefixime were increased by about 70% and 50%, respectively, when cefixime was taken 30 minutes after a 20-mg dose of nifedipine. The rate of absorption was also increased. One suggested reason for this interaction is that the nifedipine increases the absorption of the cefixime by affecting the carrier system across the epithelial wall of the gut. It seems doubtful if this increased cefixime bioavailability is clinically important (the combination was well-tolerated) and no particular precautions would seem to be necessary on concurrent use. 

A 7-year-old boy experienced oculogyric crisis secondary to the administration of cefixime. He was treated with cefixime 8 mg/kg/day in two divided doses for a urinary tract infection. On day 7 of treatment, he developed abnormal eye movements that included periodic eye blinking and deviations without nystagmus. Prior to this presentation, he had not received any other medications other than cefixime. The drug was stopped and his symptoms ceased. Two weeks later, cefixime was reinitiated by another physician secondary to a dry cough. The abnormal eye movements recurred and cefixime was again discontinued. The eye movements again ceased within 2 days [63 ]. 

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