Cefepime dihydrochloride

Fig. 431 Calibration curve for the presence of cefepime dihydrochloride dihydrate in cefepime dihydrochloride monohydrate as determined by diffuse reflectance IR spectroscopy. (From Bugay 1999, with permission.)...

When a nonequivalence in absorption bands is identified for a polymorphic or solvate system, the band intensities can be used for a quantitative analysis of mixtures containing the various phases. Such work requires the nontrivial preparation of homogeneous calibration samples containing known amounts of the phases in question, but most workers underestimate the difficulty associated with mixing powders of potentially different morphologies. For example, the monohydrate phase of cefepime dihydrochloride consists of rods, while the dihydrate phase consists of needles, and the mixing of these could only be prop-... 

Bugay, D. E., Newman, A. W. and Findlay, W. P. Quantitation of cefepime dihydrochloride in cefepime dihydrochloride monohydrate by diffuse reflectance IR and powder X-ray diffraction techniques. /. Pharm. Biomed. Anal. 15 49—61, 1996. 

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