Cefaclor Theophylline

Extracted cefamandole, cefazolin, cefoxitin, cephapirin, chloramphenicol Simultaneous acetaminophen, N-acetylprocainamide, cefaclor, cephalexin, cephalothin, ci-metidine, miconazole, moxalactam, procainamide, sulfamethoxazole, theophylline, tobramycin, vancomycin... 

Ceftibuten and cefalexin appear not to interact with theophylline. Cefaclor has been implicated in two cases of theophylline toxicity in children, but studies in adult subjects found no pharmacokinetic interaction. 

A case report suggested that cefaclor might have been responsible for the development of theophylline toxicity in 2 children. However, a singledose study and a steady-state study in healthy adults found that cefaclor 250 mg three times daily for 8 and 9 days, respectively, had no effect on the pharmacokinetics of oral or intravenous theophylline. Although the pharmacokinetics of theophylline differ in adults and children a significant interaction with cefaclor seems unlikely. 

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