Cefaclor bactericidal

Penicillins (bactericidal inhibit cell wall crosslinking) e.g., benzylpenicillin, phenoyxmethylpenicillin, ampicillin, amoxicillin, flu-cloxacillin, methicillin, piperacillin Cephalosporins (bactericidal inhibit cell wall crosslinking) e.g., cefaclor, cefalexin, cefradine, cefuroxime, cefazolin, cefotaxime, ceftriaxone, cefoxitin, cefsulodin, ceftazidime, ceftizoxime Monobactams (bactericidal, P-lactam-like activity) e.g., aztreonam... 

Cephalosporins are semisynthetic antibiotics obtained from the fungus Cephalo-sporium. These bactericidal agents act in a similar way to that of penicillins. There are different types of cephalosporins available first-generation (cefazolin, cefadroxil) second-generation (cefuroxime, cefaclor) third-generation (cefotaxime, cefoperazone) and fourth-generation (cefpirome). 

The rapid bactericidal effect of cefaclor against susceptible organisms at levels at or near the inhibitory concentrations is well documented (Sanders, 1977 Silver et al., 1977). The comparative efficacy of cefaclor, cephalexin, and ampicillin in protecting mice from lethal effects of bacterial infections intraperitoneally administered is shown in Table IX. Note a 10-fold advantage in median effective dose (ED50) for cefaclor over cephalexin against certain strains of S. pneumoniae and the activity of cefaclor against strains of H. influenzae resistant to ampicillin. 

Among the biological properties of cefaclor just reviewed, rapid oral absorption, metabolic stability, renal excretion, bactericidal activity, antimicrobial spectral characteristics, and low toxicity potential make this antibiotic an especially attractive candidate for use in the treatment of bacterial upper respiratory tract and urinary tract infections caused by susceptible bacteria. 

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See also in sourсe #XX -- [ ]

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