CD Analysis of Side-Chain Chromophores on Saccharides

The ICD of the dyes bound to saccharides through an ionic coupling or hydrophobic interaction may remain a conflicting problem. The side-chain chromophores covalently bound to saccharides permit CD bands in the far or near ultraviolet region. These side-chain chromophores can exhibit CD and thus provide more definitive information on the conformation of saccharide moieties. Thus, acetamide CD has been observed to reflect polymer secondary structure of glycosaminoglycans, which are the connective-tissue proteoglycans. 

Glycosaminoglycan CD is complicated by the presence of two chromophoric groups with overlapping electronic transitions, the carboxyl and acetamide substituents. 

4 Benzoates Exciton Rule for Determining die Anomeric Configuration in Saccharides 

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