CCVJ triethyleneglycol ester

Fig. 14 Water-soluble CCVJ, hydrophobic CCVJ farnesyl ester (FCVJ) for cell membrane applications [88], and hydrophilic CCVJ triethyleneglycol ester (CCVJ-TEG) [89]...

Most of the molecules introduced in this chapter are hydrophobic. Even those molecules that have been functionalized to improve water-solubility (for example, CCVJ and CCVJ triethyleneglycol ester 43, Fig. 14) contain large hydrophobic structures. In aqueous solutions that contain proteins or other macromolecules with hydrophobic regions, molecular rotors are attracted to these pockets and bind to the proteins. Noncovalent attraction to hydrophobic pockets is associated with restricted intramolecular rotation and consequently increased quantum yield. In this respect, molecular rotors are superior protein probes, because they do not only indicate the presence of proteins (similar to antibody-conjugated fluorescent markers), but they also report a constricted environment and can therefore be used to probe protein structure and assembly. 

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See also in sourсe #XX -- [ ]

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