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Chiral columns cavity-based

TABLE 2 Cavity-Based Chiral Columns Commonly Used in Pharmaceutical HPLC Method Development Screening Systems... [Pg.259]

A chiral selector can also be dissolved in the IL solvent and be subsequently coated on the capillary wall [38]. In this approach, the achiral [C4CiIm]Cl was used to dissolve permethylated p-cyclodextrin (p-PM) and dimethylated P-cyclodextrin (p-DM). The chromatographic separations obtained from these two columns were compared to two commercially available CSPs based on p-PM and p-DM dissolved in polydimethylsiloxane. From a set of 64 chiral molecules separafed by fhe commercial p-PM column, only 21 of the molecules were enantioresolved by the IL-based p-PM column. Likewise, from a collecfion of 80 analytes separated by the p-DM column, only 16 analytes could be separated on the IL-based p-DM column. The authors also noted a considerable enhancement in the separation efficiency of fhe IL-based CSPs. This resulf, coupled to fhe loss of enantioselecfivify for mosf separations, suggests that the imidazolium cation may occupy the cavity of the cyclodextrin preventing the analyte-cyclodextrin inclusion complex-ation that is crucial for chiral recognition. The ability for ILs to form inclusion complexes wifh cyclodextrin molecules has been recently studied by Tran and coworkers using near-infrared spectromefry [39]. [Pg.156]


See other pages where Chiral columns cavity-based is mentioned: [Pg.253]    [Pg.65]    [Pg.966]    [Pg.24]    [Pg.65]    [Pg.102]    [Pg.65]    [Pg.373]    [Pg.810]    [Pg.405]    [Pg.212]    [Pg.694]    [Pg.248]    [Pg.239]   


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Chiral cavity

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