Catecholamines analogs

In one patient who took 900 mg of phenelzine, there was a marked excess of urinary and plasma catecholamines, analogous to pheochromocytoma, and the patient was successfully managed with alpha-adrenoceptor antagonists (44). In another patient, who probably... 

O /H 1 R Sulfonamides Weak acids, used rather as equivalents of phenolic hydroxyls in the design of catecholamine analogs von Kohler et... 

Catecholamine analogs, such as mescaline and amphetamine have potent psychopharmacological properties. 

Table I. Catecholamine Analogs with a Substituted Amino Group in the Meta Position (30)...

Table III. Catecholamine Analogs With a Bridge Between the Meta-OH or OH-Slmulating Group...

The antihypertensive effects of a-methylated catecholamine analogs have been studied.In renal hypertensive rats, prolonged treatment with a-methyldopa, a-methyl- m-tyrosine, a-meth-yltyrosine or metaraminol produces dose-dependent decreases in blood pressure and dose-dependent depletion of myocardial catecholamines. The same order of relative activities was found in regard to noradrenaline depletion and antihypertensive effect, but there was no relationship between the degree of catecholamine depletion and the intensity of the hypotensive effect. 

The release of catecholamines has been studied mainly in the adrenal medulla, which is analogous to the nerve cell. In the medulla, the neuronal impulse releases ACh... 

The ion-exchange mechanism of exfracfion does nof occur only for amino acids. We observed if also for cafecholamines [26]. These compounds are efficiently extracted into ILs in the cationic form, af pH 1-8. Af fhese pH, the primary (dopamine) or secondary (adrenaline and dobutamine) amino groups are protonated (catecholamines are oxidized in alkaline solutions at pH > 8). By analogy with amino acids, extraction may be described by the cation-exchange reaction ... 

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