Catecholamine reuptake pump

Catecholamine reuptake pump Nerve terminal transporter responsibie for recycling catecholamine transmitters after release into the synapse... 

The principal mechanism for the deactivation of released catecholamines is, however, not enzymatic destmction but reuptake into the nerve ending. The presynaptic membrane contains an amine pump—a saturable, high-affinity, Na" -dependent active-transport system that requires energy for its function. The recycled neurotransmitter is capable of being released again, as experiments with radiolabelled [ H]NE have shown, and can be incorporated into chromaffin granules as well. Many drugs interfere with neurotransmitter reuptake and metabolism, as discussed in subsequent sections. 

The other group of drugs acting on catecholamine recycling are the true reuptake inhibitors, which block the amine pump of the reuptake-1 mechanism in central adrenergic, dopaminergic, and serotonergic neurons. 

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