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Catalyzed vinylogous Mukaiyama Mannich

New Au(III)-pyridine-2-carboxylate complexes were developed to catalyze the intramolecular reaction between furan and acetylene to form phenols <04AE(G)6545>. These pre-catalysts provide higher reaction conversion than AuClj. The Lewis acid catalyzed vinylogous Mukaiyama-Mannich addition of trimethylsilyloxyfuran to aldimines, that generates 6-amino-Y-butenolide intermediates, was applied to the synthesis of piperidines... [Pg.144]

Vinylogous Mukaiyama Mannich Reactions of Silyl Dienolates I 165 Table 5.4 Brens ted acid catalyzed vinylogous Mannich reaction according to Akiyama et al. [10],... [Pg.165]

The catalytic, enantioselective, vinylogous Mannich reaction has recently emerged as a very powerful tool in organic synthesis for the assembly of highly functionalized and optically enriched 6 amino carbonyl compounds. Two distinctly different strategies have been developed. The first approach calls for the reaction of preformed silyl dienolates as latent metal dienolates that react in a chiral Lewis acid or Bronsted acid catalyzed Mukaiyama type reaction with imines. Alternatively, unmodified CH acidic substrates such as a,a dicyanoalkenes or 7 butenolides were used in vinylo gous Mannich reactions that upon deprotonation with a basic residue in the catalytic system generate chiral dienolates in situ. [Pg.175]


See other pages where Catalyzed vinylogous Mukaiyama Mannich is mentioned: [Pg.815]    [Pg.816]    [Pg.815]    [Pg.148]    [Pg.323]   


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