Catalytic Enantioselective Additions of Alkylzinc Reagents to Imines

3 Catalytic Enantioselective Additions of Alkylzinc Reagents to Imines 

A number of important breakthroughs have led to the development of several catalytic and enantioselective addition reactions of alkylzinc reagents to imines. The first of these successful approaches was reported by Tomioka, who employed a copper-catalyzed process using chiral phosphine 272 (Equation 28) [174], In this context, a range of aromatic N-sulfonylamides such as 271 were shown to participate readily in the addition and to afford adducts in high optical purity. 

Bolm s in situ generation of diarylzinc species from boronic acids and its application in asymmetric arylations of aldehydes [15] 

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