Catalyst Preparation, Reaction Conditions and Catalytic Cycle

2 Catalyst Preparation, Reaction Conditions and Catalytic Cycle 

Attention to catalyst preparation and reaction conditions is of crucial importance for the success of an Ir-catalyzed allylic substitution, because many ligands are altered by C—H activation at aryl (see above) or CH3 groups. For most reactions, tetrahydrofuran (THF) is the preferred solvent it is important that dry THF ( 35gg H20mr THF, Karl Fischer titration) is used for catalyst preparation because this step is very sensitive to water. The following procedures have been appHed. 

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