Catalyst postsynthetic modification

Engineering Metal-Organic Frameworks Catalysts by Postsynthetic Modification... 

Tanabe KK, Cohen SM (2009) Engineering a metal-organic framework catalyst by using postsynthetic modification. Angew Chem Int Ed 48 7424—7427... 

There are several basic approaches to the design of heterogeneous catalysts based on MOFs the use of MOFs as classical supports for an active metal, the immobilization of a catalytically active site in the framework per se (in the inorganic node or in the organic linker), host-guest interaction, postsynthetic modification of the framework, and so forth. These approaches will be discussed later in more detail. 

The use of MOFs as a support for active metals is an approach that is well known for typical heterogeneous catalysts, such as palladium/platinum on carbon or on zeolites [86]. Note that the introduction of ions of catalytically active transition metals into the framework of the synthesized MOFs can formally be considered as a postsynthetic modification as well, which we will discuss in more detail. 

MeOH. The treatment of this material with excess Ti(OiPr)4 in toluene makes it possible to obtain an active catalyst for the addition of diethylzinc to aromatic aldehydes to produce chiral secondary alcohols after hydrolysis. The study also exemplifies the postsynthetic modification of the framework. Chiral secondary alcohols were obtained, in this case, with a high enantioselectivity and a good yield. For example, the addition of diethylzinc to (i )-l-naphthaldehyde allows for the synthesis of (i )-l-(l-naphthyl)-propanol with 90.0% ee and complete conversion. 

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