Catalysis Uncoupling with Hydrogen Peroxide Production or Dioxygen Bond Scission

The Second Branchpoint of P450 Catalysis Uncoupling with Hydrogen Peroxide Production or Dioxygen Bond Scission 

The formation of the hydroperoxo-ferric heme intermediate is a common step in the different pathways, in oxygenases and peroxidases. In heme en2ymes, this intermediate can undergo 

In peroxidases, both protons are essential for heterol)Tic scission of the 0-0 bond and subsequent formation of Compound I. Hence, in order for a similar mechanism in P450 to occur, the enzyme must deliver two protons to provide 

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