Catalysis molecularly imprinted silicas

Reactions inside imprinted cavities are another interesting area. Of great importance to the field is catalysis with imprinted polymers and imprinted silicas. For a broader application of molecularly imprinted polymers further improvement of the method will be necessary. The following problems are in the forefront of investigation today ... 

The authors noted "...This enantioselective catalysis should extend the seope of our strategy for tailored specific catalysts by the molecular imprinting method...". A review of these works exists Indeed, these results are of great interest, but it is necessary to note that Kaiser and Anderson were unable to repeat the results with the benzamide imprinted silicas. Their failure probably was the result of a short lifetime for the specific properties of such Al-doped silica gels. 

Cammidge, A.N. Baines, N.J. Bellingham, R.K. Synthesis of heterogeneous palladium catalyst assemblies by molecular imprinting. Chem. Commun. 2001, 2588-2589. Morihara, K. Kurihara, S. Suzuki, J. Footprint catalysis. I. A new method for designing tailor-made catalysts with substrate specificity silica (alumina) catalysts for butanolysis of benzoic anhydride. Bull. Chem. Soc. Jpn. 1988, 61, 3991-3998. Morihara, K. Nishihata, E. Kojima, M. Miyake, S. Footprint catalysis. II. molecular recognition of footprint catalytic sites. Bull. Chem. Soc. Jpn. 1988, 61, 3999-4003. Shimada, T. Makanishi, K. Morihara, K. Footprint catalysis. IV. structural effects of templates on catalytic behavior of imprinted footprint cavities. Bull. Chem. Soc. Jpn. 1992, 65, 954-958. 

Heilmann, J. Maier, W.F. Problems in selective catalysis with molecular imprints in silica—selective lactones formation from hydroxyesters in micropores. Z Naturforsch 1995, 50b, 460-468. 

Morihara K., Kurokawa M., Kamata Y. and Shimada T. (1992) Enzymelike enantioselective catalysis over chiral Molecular Footprint cavities on a silica (alumina) gel surface, J. Chem. Soc., Chem. Comm., 358-360. Davis M E., Katz A. and Ahmad W.R. (1996) Rational catalysts design via imprinted nanostructured materials, Chem. Mater., 8,1820-1839. 

Matsuishi, T. Shimada, T. Morihara, K. Definitive evidence for enantioselective catalysis over molecular footprint catalytic cavities chirally imprinted on a silica (alumina) gel surface. Chem. Lett. 1992, 1921-1924. 

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